Acute effects of adrenaline on platelet aggregation and kinetics in vivo.
Identifieur interne : 008139 ( Main/Exploration ); précédent : 008138; suivant : 008140Acute effects of adrenaline on platelet aggregation and kinetics in vivo.
Auteurs : RBID : pubmed:1932177English descriptors
- KwdEn :
- Animals, Blood Platelets (physiology), Cardiovascular Diseases (blood), Dogs, Epinephrine (pharmacology), Indium Radioisotopes (diagnostic use), Liver (radionuclide imaging), Platelet Aggregation (drug effects), Spleen (radionuclide imaging), Stress, Physiological (blood), Stress, Psychological (blood).
- MESH :
- chemical , diagnostic use : Indium Radioisotopes.
- chemical , pharmacology : Epinephrine.
- blood : Cardiovascular Diseases, Stress, Physiological, Stress, Psychological.
- drug effects : Platelet Aggregation.
- physiology : Blood Platelets.
- radionuclide imaging : Liver, Spleen.
- Animals, Dogs.
Abstract
The platelet (Plt) contribution to cardiovascular events triggered by adrenergic stress is supported by some experimental and necropsy data, but a cause and effect link and mechanism have not yet been clearly demonstrated. Adrenergic stress was simulated by three successive adrenaline (A) injections (80 micrograms/kg) in anesthetized dogs previously infused with indium111 labelled Plt (111In-Plt) for a gamma-camera study. Adrenaline induced an acute and significant decrease in the Plt aggregation ratio (PAR) and a parallel decrease in the Plt count as well as in the circulating 111In-Plt, mirroring a significant and persistent Plt sequestration mainly in the liver and spleen. The long-lasting and significant decrease in the circulating Plt count observed 15 min after each A injection can be explained by a persistent retention of Plt. Further studies are in progress in order to disclose if this corresponds to platelet microaggregate embolization in microvessels of the organs so far analysed. If this postulate can be confirmed the hypothesis of an adrenergic stress triggering of ischemic events will be justified.
PubMed: 1932177
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Adrenergic stress was simulated by three successive adrenaline (A) injections (80 micrograms/kg) in anesthetized dogs previously infused with indium111 labelled Plt (111In-Plt) for a gamma-camera study. Adrenaline induced an acute and significant decrease in the Plt aggregation ratio (PAR) and a parallel decrease in the Plt count as well as in the circulating 111In-Plt, mirroring a significant and persistent Plt sequestration mainly in the liver and spleen. The long-lasting and significant decrease in the circulating Plt count observed 15 min after each A injection can be explained by a persistent retention of Plt. Further studies are in progress in order to disclose if this corresponds to platelet microaggregate embolization in microvessels of the organs so far analysed. If this postulate can be confirmed the hypothesis of an adrenergic stress triggering of ischemic events will be justified.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">1932177</PMID><DateCreated><Year>1991</Year><Month>12</Month><Day>06</Day></DateCreated><DateCompleted><Year>1991</Year><Month>12</Month><Day>06</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0368-3249</ISSN><JournalIssue CitedMedium="Print"><Volume>35</Volume><Issue>2</Issue><PubDate><MedlineDate>1991 Apr-Jun</MedlineDate></PubDate></JournalIssue><Title>Journal of nuclear biology and medicine (Turin, Italy : 1991)</Title><ISOAbbreviation>J Nucl Biol Med</ISOAbbreviation></Journal><ArticleTitle>Acute effects of adrenaline on platelet aggregation and kinetics in vivo.</ArticleTitle><Pagination><MedlinePgn>105-10</MedlinePgn></Pagination><Abstract><AbstractText>The platelet (Plt) contribution to cardiovascular events triggered by adrenergic stress is supported by some experimental and necropsy data, but a cause and effect link and mechanism have not yet been clearly demonstrated. Adrenergic stress was simulated by three successive adrenaline (A) injections (80 micrograms/kg) in anesthetized dogs previously infused with indium111 labelled Plt (111In-Plt) for a gamma-camera study. Adrenaline induced an acute and significant decrease in the Plt aggregation ratio (PAR) and a parallel decrease in the Plt count as well as in the circulating 111In-Plt, mirroring a significant and persistent Plt sequestration mainly in the liver and spleen. The long-lasting and significant decrease in the circulating Plt count observed 15 min after each A injection can be explained by a persistent retention of Plt. Further studies are in progress in order to disclose if this corresponds to platelet microaggregate embolization in microvessels of the organs so far analysed. If this postulate can be confirmed the hypothesis of an adrenergic stress triggering of ischemic events will be justified.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fortunato</LastName><ForeName>J S</ForeName><Initials>JS</Initials><Affiliation>Center for the Physiology of Haemostasis (INIC), Oporto Medical School, Porto, Portugal.</Affiliation></Author><Author ValidYN="Y"><LastName>Pinheiro</LastName><ForeName>M J</ForeName><Initials>MJ</Initials></Author><Author ValidYN="Y"><LastName>Monteiro</LastName><ForeName>M C</ForeName><Initials>MC</Initials></Author><Author ValidYN="Y"><LastName>Rodrigues</LastName><ForeName>M A</ForeName><Initials>MA</Initials></Author><Author ValidYN="Y"><LastName>Amaral</LastName><ForeName>I</ForeName><Initials>I</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>ITALY</Country><MedlineTA>J Nucl Biol Med</MedlineTA><NlmUniqueID>9110209</NlmUniqueID><ISSNLinking>0368-3249</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>YKH834O4BH</RegistryNumber><NameOfSubstance>Epinephrine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Blood Platelets</DescriptorName><QualifierName MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cardiovascular Diseases</DescriptorName><QualifierName MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Dogs</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Epinephrine</DescriptorName><QualifierName MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Liver</DescriptorName><QualifierName MajorTopicYN="N">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Platelet Aggregation</DescriptorName><QualifierName MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Spleen</DescriptorName><QualifierName MajorTopicYN="N">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Stress, Physiological</DescriptorName><QualifierName MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Stress, Psychological</DescriptorName><QualifierName MajorTopicYN="N">blood</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1991</Year><Month>4</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1991</Year><Month>4</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1991</Year><Month>4</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1932177</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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